126Doxorubicin Loaded on Aminosilane Modified Superparamagnetic Magnetic Nanoparticles and Its Characterization


Abstract:

In the past few decades, Magnetite (Fe3O4) nanoparticles have attracted growing research interest. This material has a vast range of application in medicine and drug delivery, specifacally Coated magnetic particles, called carriers, which are very useful in manifacturing chemotherapeutic drugs. In this work,  Magnetite nanoparticles (NPs) were synthesized by co-precipitating Fe2+ and Fe3+ in an ammonia solution. Magnetite NPs coated with 3-aminopropyltriethoxysilane (APTES) were prepared by silanization. Then Doxorubicin (DOX) drug was loaded at modified magnetic nanoparticles. The structural, morphological and magnetic properties of as-prepared sample were characterization by X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectra, scanning electron microscopy/energy dispersive x-ray analysis (SEM-EDAX) and magnetic measurements were investigated using vibrating sample magnetometer (VSM). We demonstrate that the drug DOX is attached to the nanoparticles surface, that the binding of DOX to the nanoparticles was confirmed by FT-IR analysis. The potential of doxorubicin against the cancer cells K562 was evaluated using the MTT assay. That, cell culture experiments demonstrated the potential of these nanosystems as an effective dual targeting nanoplatform for the delivery of anticancer drugs.

Keywords: loaded, Doxorubicin, magnetic nanoparticles, 3-aminopropyl tri methoxysilan, superparamagnetic

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